丝氨酸
转移酶
生物化学
苏氨酸
酶
生物
磷酸化
化学
癌症研究
细胞生物学
计算生物学
作者
Xing Liu,Jing Wang,Yaoxian Xiang,Kangjie Wang,Dong Yan,Yingying Tong
标识
DOI:10.1186/s13578-024-01301-w
摘要
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues in proteins. Extensive research indicates its impact on target protein stability, activity, and interactions. O-linked N-acetylglucosamine transferase (OGT) is a critical enzyme that catalyzes O-GlcNAc modification, responsible for adding O-GlcNAc to proteins. OGT and O-GlcNAcylation are overexpressed in many tumors and closely associated with tumor growth, invasion, metabolism, drug resistance, and immune evasion. This review delineates the biochemical functions of OGT and summarizes its effects and mechanisms in tumors. Targeting OGT presents a promising novel approach for treating human malignancies.
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