Novel variant WNK4 gene identified in early-onset severe hypertension: a case report

Learning point for cliniciansWith-no-lysine (WNK) kinase variants can cause both typical familial hyperkalemic hypertension (FHHt) and earlyonset hypertension with no electrolyte disorder.We report a novel WNK4 variant G1081E identified in a patient with early-onset severe hypertension.Hydrochlorothiazide has a dramatic effect on controlling her blood pressure.