化学
烯丙基重排
对映选择合成
替代(逻辑)
催化作用
铜
区域选择性
组合化学
取代反应
有机化学
立体化学
药物化学
计算机科学
程序设计语言
作者
Tingrui Yin,Chunhui Zhao,Chaochao Yao,Hao-Dong Qian,Zisai Yuan,Hao Peng,Yadong Feng,Hao Xu
标识
DOI:10.1021/acs.orglett.4c02012
摘要
Chiral coumarins and their derivatives are prominent bioactive structural units present in a wide range of natural products and pharmaceutical candidates. Therefore, the development of straightforward and efficient methodologies for the synthesis of readily functionalized chiral coumarins is of significant interest. Herein we report an enantioselective copper-catalyzed yne-allylic substitution of coumarins, resulting in a highly regioselective synthesis of diverse new classes of chiral coumarin derivatives with high efficiency and excellent functional group tolerance. Subsequent versatile transformations further demonstrate the substantial synthetic potential of this strategy in the field of biochemical research.
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