鼻病毒
生物
炎症
马车
免疫学
肺炎链球菌
微生物学
肺炎球菌感染
病毒学
病毒
医学
抗生素
病理
作者
Elena Mitsi,Elissavet Nikolaou,André Fernando Nascimento Gonçalves,Annie Blizard,Helen Hill,Madlen Farrar,Angela Hyder-Wright,Oluwasefunmi Akeju,Josh Hamilton,Ashleigh Howard,Filora Elterish,Carla Solórzano,Ryan Robinson,Jesús Reiné,Andrea M. Collins,Stephen B. Gordon,Richard Moxon,Jeffrey N. Weiser,Debby Bogaert,Daniela M. Ferreira
标识
DOI:10.1016/j.chom.2024.07.024
摘要
Epidemiological studies report the impact of co-infection with pneumococcus and respiratory viruses upon disease rates and outcomes, but their effect on pneumococcal carriage acquisition and bacterial load is scarcely described. Here, we assess this by combining natural viral infection with controlled human pneumococcal infection in 581 healthy adults screened for upper respiratory tract viral infection before intranasal pneumococcal challenge. Across all adults, respiratory syncytial virus (RSV) and rhinovirus asymptomatic infection confer a substantial increase in secondary infection with pneumococcus. RSV also has a major impact on pneumococcal density up to 9 days post challenge. We also study rates and kinetics of bacterial shedding through the nose and oral route in a subset. High levels of pneumococcal colonization density and nasal inflammation are strongly correlated with increased odds of nasal shedding as opposed to cough shedding. Protection against respiratory viral infections and control of pneumococcal density may contribute to preventing pneumococcal disease and reducing bacterial spread.
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