肿瘤微环境
转化生长因子
信号转导
癌症研究
癌症
发病机制
肿瘤进展
生长因子
转化生长因子β
疾病
医学
生物
免疫学
肿瘤细胞
细胞生物学
受体
内科学
作者
Max Kam-Kwan Chan,Emily Lok-Yiu Chan,Zoey Zeyuan Ji,Alex Siu Wing Chan,Chunjie Li,Kam-Tong Leung,Ka Fai To,Patrick Ming-Kuen Tang
标识
DOI:10.37349/etat.2023.00137
摘要
Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, both anticancer and protumoral actions are reported. Interestingly, increasing evidence suggests that TGF-β enhances disease progression and drug resistance via immune-modulatory actions in the tumor microenvironment (TME) of solid tumors. A better understanding of its regulatory mechanisms in the TME at the molecular level can facilitate the development of precision medicine to block the protumoral actions of TGF-β in the TME. Here, the latest information about the regulatory mechanisms and translational research of TGF-β signaling in the TME for therapeutic development had been summarized.
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