原卟啉IX
医学
病理
脑瘤
荧光
病态的
脑组织
癌症研究
内科学
物理
量子力学
作者
Omer Doron,Iddo Paldor
出处
期刊:PubMed
日期:2023-04-01
卷期号:162 (4): 216-220
摘要
The 5-aminolevulinic acid (5-ALA) fluorescence-guided resection is an essential part of the current state-of-the-art treatment of primary malignant brain tumors. Metabolized by tumor cells, creating Protoporphyrin-IX, which is fluorescent under UV light emitted from the microscope, 5-ALA facilitates visual distinction between the tumor and the normal brain tissue surrounding it, coloring it pink. This real-time diagnostic feature was shown to lead to more complete removal of the tumor and confers a survival benefit. Nevertheless, despite the high sensitivity and specificity that was described using this method, there are other pathological processes in which 5-ALA is being metabolized that fluoresce similarly to a malignant glial tumor.
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