Gender-specific association of adverse childhood experiences with frailty index level and trajectory in China

医学 虚弱指数 中国 联想(心理学) 索引(排版) 弹道 老年学 人口学 法学 计算机科学 政治学 万维网 天文 认识论 物理 哲学 社会学
作者
Qīng Wáng
出处
期刊:Maturitas [Elsevier BV]
卷期号:170: 1-8 被引量:3
标识
DOI:10.1016/j.maturitas.2023.01.011
摘要

The determinants of gender differences in frailty remain unknown but may include social factors. International attention is increasingly focusing on the adverse childhood experiences of women. This study therefore examined the gender-specific association of adverse childhood experiences with frailty index level and trajectory.This population-based study used data from the China Health and Retirement Longitudinal Study, with a nationally representative sample of people aged 45 years or more. The frailty index was based on 41 health measurements, and 18 types of adverse childhood experiences were examined. Weighted ordered logistic models were used with additive interaction.Compared with those exposed to one or no adverse events, exposure to two or three childhood adverse experiences was associated with a 44 % (95%CI: 1.16-1.80) increase in the likelihood of frail status for women, but not significantly associated with the likelihood of frail status for men. Additionally, for men and women, experiencing four or more adversities was associated with a 69 % (95%CI: 1.36-2.09) and a 138 % (95%CI: 1.93-2.94) increase in the likelihood of frail status, respectively. A similar association was found between accumulative scores for adverse childhood experiences and trajectory of the frailty index (men vs. women: OR of exposure to two or three adversities: 1.17 (95%CI: 0.84-1.64) vs. 1.26 (95%CI: 1.02-1.56); OR of exposure to four or more adversities: 1.70 (95%CI: 1.24-2.34) vs. 2.12 (95%CI: 1.70-2.63)). The greatest increase in risk of frailty was observed among men and women experiencing a high level of adversity, followed by socioeconomic deprivation and intrafamilial aggression. There was a significant additive interaction between women and childhood socioeconomic deprivation or a high level of adversity. The risk of being frail or having a rapidly increasing frailty index trajectory for women with a high level of adversity was approximately 4.34 (95%CI: 3.36-5.59) and 4·07 (95%CI: 3·34-4.96) times higher than that for men with a low level of adversity. However, gender differences were not found in the effects of childhood intrafamilial aggression.Men and women routinely experienced adult frailty as a result of adverse childhood events. The biological interaction between women and adverse childhood experiences was evident, with women's frailty being more sensitive to childhood socioeconomic deprivation and a high level of adversity. The findings have important implications for reducing the risk of frailty by mitigating early life stress, especially among women.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
香蕉觅云应助maying0318采纳,获得10
1秒前
1秒前
无花果应助碧蓝碧凡采纳,获得10
2秒前
_hhhjhhh完成签到,获得积分10
2秒前
Leo完成签到,获得积分10
3秒前
4秒前
淘气科研发布了新的文献求助10
4秒前
小徐801完成签到,获得积分10
4秒前
5秒前
5秒前
wwk完成签到,获得积分10
5秒前
光亮不平完成签到,获得积分10
6秒前
llwxx完成签到,获得积分10
6秒前
梁大海发布了新的文献求助10
6秒前
甜蜜的楷瑞应助_hhhjhhh采纳,获得10
7秒前
諵十一完成签到,获得积分10
7秒前
zqingqing完成签到,获得积分10
8秒前
yize完成签到,获得积分10
9秒前
10秒前
10秒前
崔悦欣发布了新的文献求助10
10秒前
谨慎的擎宇完成签到,获得积分10
11秒前
Thomas完成签到,获得积分10
12秒前
小白鞋完成签到 ,获得积分10
12秒前
maying0318发布了新的文献求助10
14秒前
宣以晴完成签到,获得积分10
14秒前
Nnn完成签到,获得积分10
15秒前
baby完成签到,获得积分10
18秒前
123完成签到,获得积分10
18秒前
19秒前
学术牛马完成签到,获得积分10
19秒前
sl发布了新的文献求助10
21秒前
完美的鹤完成签到,获得积分10
22秒前
hky完成签到,获得积分10
23秒前
TTTHANKS完成签到 ,获得积分10
24秒前
WW完成签到,获得积分10
24秒前
LL完成签到,获得积分10
25秒前
量子星尘发布了新的文献求助10
25秒前
小马的可爱老婆2完成签到,获得积分10
25秒前
缥缈纲完成签到,获得积分10
26秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029