炎症
活性氧
化学
氧化应激
唑来膦酸
小分子
癌症研究
细胞生物学
纳米技术
生物化学
材料科学
医学
免疫学
生物
外科
作者
Xiaoxue Fu,Xiaojuan Yu,Junhao Jiang,Jiaxin Yang,Lu Chen,Zhangyou Yang,Chao Yu
标识
DOI:10.1038/s41467-022-34248-y
摘要
Considering that intravascular reactive oxygen species (ROS) and inflammation are two characteristic features of the atherosclerotic microenvironment, developing an appropriate strategy to treat atherosclerosis by synergistically regulating ROS and inflammation has attracted widespread attention. Herein, a special molecule, zoledronic acid, containing imidazole and bisphosphonate groups, was selected for the first time to assist the assembly of cerium ions and produce functionalized ceria-zoledronic acid nanocomposites (CZ NCs). It not only serves as a new carrier for different kinds of drugs (e.g. probucol, PB) but also exerts an efficient multienzyme activity to achieve collaborative therapy. More importantly, platelet membrane-coated biomimetic nanoplatform (PCZ@PB NCs) specifically accumulate at inflammatory atherosclerotic lesions, synergistically regulate ROS levels and inflammation, and efficiently inhibit foam cell formation. This novel assembly method can also be applied in the treatment of many other diseases associated with oxidative stress and inflammation.
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