Child maltreatment and telomere length in middle and older age: retrospective cohort study of 141 748 UK Biobank participants

端粒 队列 医学 性虐待 身体虐待 回顾性队列研究 虐待儿童 毒物控制 萧条(经济学) 心理学 伤害预防 精神科 人口学 内科学 遗传学 生物 医疗急救 DNA 经济 社会学 宏观经济学
作者
Ziyi Zhou,K.W. Lo,Ko Ling Chan,Rachel S Y Chung,Jill P. Pell,Helen Minnis,Paul G. Shiels,Patrick Ip,Frederick K. Ho
出处
期刊:British Journal of Psychiatry [Cambridge University Press]
卷期号:223 (2): 377-381
标识
DOI:10.1192/bjp.2023.33
摘要

There is evidence that child maltreatment is associated with shorter telomere length in early life.This study aims to examine if child maltreatment is associated with telomere length in middle- and older-age adults.This was a retrospective cohort study of 141 748 UK Biobank participants aged 37-73 years at recruitment. Leukocyte telomere length was measured with quantitative polymerase chain reaction, and log-transformed and scaled to have unit standard deviation. Child maltreatment was recalled by participants. Linear regression was used to analyse the association.After adjusting for sociodemographic characteristics, participants with three or more types of maltreatment presented with the shortest telomere lengths (β = -0.05, 95% CI -0.07 to -0.03; P < 0.0001), followed by those with two types of maltreatment (β = -0.02, 95% CI -0.04 to 0.00; P = 0.02), referent to those who had none. When adjusted for depression and post-traumatic stress disorder, the telomere lengths of participants with three or more types of maltreatment were still shorter (β = -0.04, 95% CI -0.07 to -0.02; P = 0.0008). The telomere lengths of those with one type of maltreatment were not significantly different from those who had none. When mutually adjusted, physical abuse (β = -0.05, 95% CI -0.07 to -0.03; P < 0.0001) and sexual abuse (β = -0.02, 95% CI -0.04 to 0.00; P = 0.02) were independently associated with shorter telomere length.Our findings showed that child maltreatment is associated with shorter telomere length in middle- and older-aged adults, independent of sociodemographic and mental health factors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
甜蜜发带发布了新的文献求助10
1秒前
摩卡发布了新的文献求助10
2秒前
凡迪亚比应助Xw采纳,获得20
4秒前
gsj完成签到,获得积分10
7秒前
8秒前
9秒前
秋天完成签到,获得积分10
10秒前
淡定的惜关注了科研通微信公众号
13秒前
Zhy发布了新的文献求助10
13秒前
14秒前
蛋挞完成签到,获得积分10
16秒前
李健应助Junning采纳,获得10
18秒前
18秒前
tingting9发布了新的文献求助10
19秒前
20秒前
爆米花应助mark采纳,获得10
21秒前
21秒前
爱看文献的小恐龙完成签到,获得积分10
22秒前
小饼干完成签到 ,获得积分10
24秒前
萧瑟处完成签到 ,获得积分10
25秒前
25秒前
26秒前
孙燕应助鹤鸣采纳,获得30
27秒前
28秒前
loski发布了新的文献求助10
30秒前
随便不放假完成签到 ,获得积分10
31秒前
淡定的惜发布了新的文献求助10
33秒前
威武的亦绿完成签到,获得积分10
33秒前
木丁完成签到,获得积分10
34秒前
34秒前
37秒前
量子星尘发布了新的文献求助30
39秒前
孙燕应助成就山河采纳,获得10
40秒前
41秒前
领导范儿应助幸福大白采纳,获得30
42秒前
谓风发布了新的文献求助10
42秒前
43秒前
q1356478314应助天白采纳,获得10
43秒前
Hanni完成签到 ,获得积分10
43秒前
44秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174