Child maltreatment and telomere length in middle and older age: retrospective cohort study of 141 748 UK Biobank participants

端粒 队列 医学 性虐待 身体虐待 回顾性队列研究 虐待儿童 毒物控制 萧条(经济学) 心理学 伤害预防 精神科 人口学 内科学 遗传学 生物 医疗急救 DNA 经济 社会学 宏观经济学
作者
Ziyi Zhou,K.W. Lo,Ko Ling Chan,Rachel S Y Chung,Jill P. Pell,Helen Minnis,Paul G. Shiels,Patrick Ip,Frederick K. Ho
出处
期刊:British Journal of Psychiatry [Cambridge University Press]
卷期号:223 (2): 377-381
标识
DOI:10.1192/bjp.2023.33
摘要

There is evidence that child maltreatment is associated with shorter telomere length in early life.This study aims to examine if child maltreatment is associated with telomere length in middle- and older-age adults.This was a retrospective cohort study of 141 748 UK Biobank participants aged 37-73 years at recruitment. Leukocyte telomere length was measured with quantitative polymerase chain reaction, and log-transformed and scaled to have unit standard deviation. Child maltreatment was recalled by participants. Linear regression was used to analyse the association.After adjusting for sociodemographic characteristics, participants with three or more types of maltreatment presented with the shortest telomere lengths (β = -0.05, 95% CI -0.07 to -0.03; P < 0.0001), followed by those with two types of maltreatment (β = -0.02, 95% CI -0.04 to 0.00; P = 0.02), referent to those who had none. When adjusted for depression and post-traumatic stress disorder, the telomere lengths of participants with three or more types of maltreatment were still shorter (β = -0.04, 95% CI -0.07 to -0.02; P = 0.0008). The telomere lengths of those with one type of maltreatment were not significantly different from those who had none. When mutually adjusted, physical abuse (β = -0.05, 95% CI -0.07 to -0.03; P < 0.0001) and sexual abuse (β = -0.02, 95% CI -0.04 to 0.00; P = 0.02) were independently associated with shorter telomere length.Our findings showed that child maltreatment is associated with shorter telomere length in middle- and older-aged adults, independent of sociodemographic and mental health factors.
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