核梭杆菌
光动力疗法
光毒性
声动力疗法
癌症研究
转移
结直肠癌
体内
医学
治疗效果
活性氧
细胞凋亡
联合疗法
癌症
药理学
化学
体外
内科学
生物
牙龈卟啉单胞菌
生物化学
有机化学
生物技术
牙周炎
作者
Xiao Qu,F Yin,Manman Pei,Qian Chen,Yuanyuan Zhang,Shengwei Lu,Xuelian Zhang,Ziyuan Liu,Xinyao Li,Hangrong Chen,Yang Zhang,Huanlong Qin
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-05-18
卷期号:17 (12): 11466-11480
被引量:40
标识
DOI:10.1021/acsnano.3c01308
摘要
Intratumoral pathogens can contribute to cancer progression and affect therapeutic response. Fusobacterium nucleatum, a core pathogen of colorectal cancer (CRC), is an important cause of low therapeutic efficacy and metastasis. Thus, the modulation of intratumoral pathogens may provide a target for cancer therapy and metastasis inhibition. Herein, we propose an intratumoral F. nucleatum-modulating strategy for enhancing the therapeutic efficacy of CRC and inhibiting lung metastasis by designing an antibacterial nanoplatform (Au@BSA-CuPpIX), which produced reactive oxygen species (ROS) under ultrasound and exhibited strong antibacterial activity. Importantly, Au@BSA-CuPpIX reduced the levels of apoptosis-inhibiting proteins by inhibiting intratumoral F. nucleatum, thereby enhancing ROS-induced apoptosis. In vivo results demonstrated that Au@BSA-CuPpIX effectively eliminated F. nucleatum to enhance the therapeutic efficacy of sonodynamic therapy (SDT) for orthotopic CRC and inhibit lung metastasis. Notably, entrapped gold nanoparticles reduced the phototoxicity of metalloporphyrin accumulated in the skin during tumor treatment, preventing severe inflammation and damage to the skin. Therefore, this study proposes a strategy for the elimination of F. nucleatum in CRC to enhance the therapeutic effect of SDT, thus providing a promising paradigm for improving cancer treatment with fewer toxic side effects and promoting the clinical translational potential of SDT.
科研通智能强力驱动
Strongly Powered by AbleSci AI