大麻酚
背景(考古学)
化学
大麻
药理学
合成大麻素
化学合成
大麻素
立体化学
生物化学
医学
生物
体外
精神科
受体
古生物学
作者
Alice Maiocchi,Marco Fumagalli,M. Vismara,A Vélez Blanco,Umberto Ciriello,Giuseppe Paladino,Stefano Piazza,Giulia Martinelli,Valerio Fasano,Mario Dell’Agli,Daniele Passarella
标识
DOI:10.1021/acs.jnatprod.4c00212
摘要
Despite millennia of therapeutic plant use, deliberate exploitation of Cannabis's diverse biomedical potential has only recently gained attention. Bioactivity studies focus mainly on cannabidiol (CBD) and tetrahydrocannabinol (THC) with limited information about the broader cannabinome's "minor phytocannabinoids". In this context, our research targeted the synthesis of minor cannabinoids containing a lateral chain with 3 or 4 carbon atoms, focusing on cannabigerol (CBG) and cannabichromene (CBC) analogues. Using known and innovative strategies, we achieved the synthesis of 11 C3 and C4 analogues, five of which were inhibitors of skin inflammation, with the CBG-C4 ester derivative emerging as the most potent compound.
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