The mediating role of sugar and lipid metabolism and systemic inflammation in the association between breakfast skipping and periodontitis: A population‐based study

牙周炎 医学 全身炎症 糖尿病 人口 内科学 优势比 体质指数 逻辑回归 血糖 生理学 碳水化合物代谢 全国健康与营养检查调查 炎症 内分泌学 环境卫生
作者
Zhikang Wang,Rui Pu,Jing Zhang,Guoli Yang
出处
期刊:Journal of Periodontology [Wiley]
标识
DOI:10.1002/jper.24-0079
摘要

Abstract Background This study investigated the association between breakfast skipping and periodontitis and the mediating role of sugar and lipid metabolism and systemic inflammation in this association using data from the Korea National Health and Nutrition Examination Survey 2016–2018. Methods This study included 11,953 participants, representing an estimated 33.9 million people. Complex sample logistic regression was used to assess the independent association between breakfast skipping and periodontitis. Subgroup analysis was conducted with modifiers including age, sex, body mass index (BMI), urban residence, education level, marital status, and diabetes. Structural equation modeling assessed potential mediation by biomarkers related to glucose and lipid metabolism along with systemic inflammation. Results The fully adjusted logistic regression model indicated a positive association between breakfast skipping and periodontitis (odds ratio [OR] = 1.234 (1.026–1.483), p = 0.025). This association was highlighted in middle‐aged (40–60 years), female, highly educated, married individuals with BMI < 25 kg/m 2 , and those in urban areas without diabetes. Blood glucose ( β ± SE = 0.006 ± 0.002, p = 0.014), triglycerides ( β ± SE = 0.004 ± 0.002, p = 0.033), and white blood cell count ( β ± SE = 0.011 ± 0.003, p = 0.003) were identified as partial mediators. Conclusions A new, independent association between breakfast skipping, and periodontitis has been discovered, which is partially mediated by sugar and lipid metabolism, and systemic inflammation. The findings provide new insights into the benefits of chrononutrition for periodontal health.
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