葛根素
伤口愈合
体内
血管生成
化学
活性氧
体外
抗菌活性
抗氧化剂
药理学
细菌
生物化学
免疫学
癌症研究
医学
生物
替代医学
病理
遗传学
生物技术
作者
Youjun Ding,Xiangyi Wu,Yi Cheng,Zhouji Ma,Yuanjin Zhao,Min Zhou
标识
DOI:10.1016/j.cej.2024.153335
摘要
Biomedical patches have garnered recognition for their efficacy in diabetic wound management. Current research efforts are focused on developing natural and efficient hydrogel patches in order to reduce inherent side effects and enhance therapeutic outcomes. In this study, we present natural multi-actives composited hydrogel patches for diabetic wound management. The novel medical patch was fabricated using freeze-dried grape peel, oligomeric proanthocyanidins (OPC) and puerarin based on spontaneous physical crosslinking. With the incorporation of OPC, the natural patch exhibited favorable photothermal antibacterial properties, effectively inhibiting S. aureus and E. coli under 808 nm near-infrared irradiation. In addition, the grape peel could induce M2 macrophage polarization and scavenge reactive oxygen species, showcasing immunomodulatory effects. Moreover, the puerarin component in the patches was discovered to promote endothelial cell proliferation and migration, thereby facilitating angiogenesis in vitro. Based on these features, we have demonstrated the antibacterial, antioxidant, anti-inflammatory, and angiogenic effects of the patches in vivo. Thus, we believe that the natural multi-actives composite patch holds significant promise for diabetic wound treatment and broader biomedical applications.
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