结核(地质)
病理
腺癌
病变
肺
壁画
医学
放射科
生物
癌症
内科学
绘画
古生物学
艺术
视觉艺术
作者
M Higashiyama,Yoshihisa Kobayashi,Jumpei Kashima,Yuji Muraoka,Hirokazu Watanabe,Masahiko Kusumoto,Shun‐ichi Watanabe,Yasushi Yatabe
标识
DOI:10.1097/pas.0000000000001938
摘要
Invasive mucinous adenocarcinoma (IMA) of the lung shares some clinicopathological features with mucinous carcinoma of other organs, such as the ovary. Sarcoma-like lesions, called mural nodules, have been reported in the cystic walls of ovarian mucinous tumors. In this study, we analyzed 213 surgically resected cases of IMA of the lung to determine whether similar mural nodule–like lesions were present. We considered abrupt discrete lesions composed of dedifferentiated tumor cells as mural nodule–like lesions. Of 213 IMAs, we identified 11 tumors with mural nodule–like lesions that were histologically categorized into three subtypes similar to those in the ovary. The sarcomatoid and anaplastic carcinoma–like nodules were composed of spindle cell proliferations and polygonal undifferentiated carcinoma, respectively. Sarcoma-like lesions mimicked sarcomatoid nodules, but the spindle cell proliferations were considered a fibroblastic reaction to the scattered, isolated clusters of tumor cells. Molecular analysis of the components of differentiated IMAs and mural nodule–like lesions revealed a clonal relationship, suggesting a spectrum of tumors with different histology. Clinicopathologically, an older age, the male sex, and smokers were significantly associated with IMAs with mural nodule–like lesions. Notably, patient outcomes were unaffected by the presence or absence of these lesions. Our findings demonstrated that IMA of the lung rarely develops mural nodule–like lesions (11 of 213, 5%). Despite a histological impression of clinical aggressiveness, there was no clear trend in patient outcomes, suggesting that pathologists should avoid overstating this mural nodule–like lesion.
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