细胞外小泡
结核分枝杆菌
蛋白质组学
微生物学
细胞外
化学
胞外囊泡
肺结核
生物
计算生物学
微泡
生物化学
细胞生物学
医学
病理
小RNA
基因
作者
Jae‐Wook Lee,Si Hyun Kim,Dongsic Choi,Jong Seok Lee,Dae-Kyum Kim,Gyeongyun Go,Seon‐Min Park,Si Hyun Kim,Jeong Hwan Shin,Chulhun L. Chang,Yong Song Gho
出处
期刊:Proteomics
[Wiley]
日期:2015-08-19
卷期号:15 (19): 3331-3337
被引量:84
标识
DOI:10.1002/pmic.201500037
摘要
The release of extracellular vesicles, also known as outer membrane vesicles, membrane vesicles, exosomes, and microvesicles, is an evolutionarily conserved phenomenon from bacteria to eukaryotes. It has been reported that Mycobacterium tuberculosis releases extracellular vesicles harboring immunologically active molecules, and these extracellular vesicles have been suggested to be applicable in vaccine development and biomarker discovery. However, the comprehensive proteomic analysis has not been performed for M. tuberculosis extracellular vesicles. In this study, we identified a total of 287 vesicular proteins by four LC-MS/MS analyses with high confidence. In addition, we identified several vesicular proteins associated with the virulence of M. tuberculosis. This comprehensive proteome profile will help elucidate the pathogenic mechanism of M. tuberculosis. The data have been deposited to the ProteomeXchange with identifier PXD001160 (http://proteomecentral.proteomexchange.org/dataset/PXD001160).
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