化学
生物分子
核酸
寡核苷酸
纳米技术
纳米材料
超分子化学
过渡金属
金属
组合化学
DNA
催化作用
分子
材料科学
有机化学
生物化学
作者
Hua Yang,Christopher K. McLaughlin,Faisal A. Aldaye,Graham D. Hamblin,Andrzej Z. Rys,Isabelle Rouiller,Hanadi F. Sleiman
出处
期刊:Nature Chemistry
[Springer Nature]
日期:2009-07-24
卷期号:1 (5): 390-396
被引量:156
摘要
Metal-nucleic acid cages are a promising new class of materials. Like metallo-supramolecular cages, these systems can use their metals for redox, photochemical, magnetic and catalytic control over encapsulated cargo. However, using DNA provides the potential to program pore size, geometry, chemistry and addressability, and the ability to symmetrically and asymmetrically position transition metals within the three-dimensional framework. Here we report the quantitative construction of metal-DNA cages, with the site-specific incorporation of a range of metals within a three-dimensional DNA architecture. Oligonucleotide strands containing specific environments suitable for transition-metal coordination were first organized into two DNA triangles. These triangles were then assembled into a DNA prism with linking strands. Metal centres were subsequently incorporated into the prisms at the pre-programmed locations. This unprecedented ability to position transition metals within a three-dimensional framework could lead to metal-DNA hosts with applications for the encapsulation, sensing, modification and release of biomolecules and nanomaterials.
科研通智能强力驱动
Strongly Powered by AbleSci AI