Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging

树枝状大分子 纳米技术 纳米医学 药物输送 生物相容性 癌症影像学 材料科学 化学 生物医学工程 癌症 医学 纳米颗粒 内科学 高分子化学 冶金
作者
Donald A. Tomalia,L.A. Reyna,Sönke Svenson
出处
期刊:Biochemical Society Transactions [Portland Press]
卷期号:35 (1): 61-67 被引量:475
标识
DOI:10.1042/bst0350061
摘要

Dendrimers are routinely synthesized as tuneable nanostructures that may be designed and regulated as a function of their size, shape, surface chemistry and interior void space. They are obtained with structural control approaching that of traditional biomacromolecules such as DNA/RNA or proteins and are distinguished by their precise nanoscale scaffolding and nanocontainer properties. As such, these important properties are expected to play an important role in the emerging field of nanomedicine. This review will describe progress on the use of these features for both targeted diagnostic imaging and drug-delivery applications. Recent efforts have focused on the synthesis and pre-clinical evaluation of a multipurpose STARBURST® PAMAM (polyamidoamine) dendrimer prototype that exhibits properties suitable for use as: (i) targeted, diagnostic MRI (magnetic resonance imaging)/NIR (near-IR) contrast agents, (ii) and/or for controlled delivery of cancer therapies. Special emphasis will be placed on the lead candidate, namely [core: 1,4-diaminobutane; G (generation)=4.5], [dendri-PAMAM(CO2Na)64]. This dendritic nanostructure (i.e. ∼5.0 nm diameter) was selected on the basis of a very favourable biocompatibility profile [The Nanotechnology Characterization Laboratory (NCL), an affiliate of the National Cancer Institute (NCI), has completed extensive in vitro studies on the lead compound and have found it to be very benign, non-immunogenic and highly biocompatible], the expectation that it will exhibit desirable mammalian kidney excretion properties and demonstrated targeting features.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
喻紫寒发布了新的文献求助10
1秒前
3秒前
弯弓丝的小张完成签到,获得积分20
3秒前
gigadrill发布了新的文献求助10
4秒前
茶蛋完成签到 ,获得积分10
4秒前
陈雷应助1123采纳,获得10
5秒前
7秒前
7秒前
korchid完成签到,获得积分10
10秒前
普普发布了新的文献求助10
12秒前
12秒前
15秒前
orixero应助laihama采纳,获得10
15秒前
gigadrill完成签到,获得积分20
17秒前
18秒前
灵试巧开完成签到 ,获得积分10
18秒前
fanhlong发布了新的文献求助10
20秒前
20秒前
阳和启蛰完成签到,获得积分10
21秒前
槑槑完成签到 ,获得积分10
22秒前
情怀应助我喜欢下雪采纳,获得10
24秒前
25秒前
27秒前
科研通AI2S应助wuyj采纳,获得10
29秒前
kk发布了新的文献求助10
29秒前
orixero应助Violette采纳,获得10
31秒前
XueZixuan完成签到,获得积分10
35秒前
我是老大应助ywh采纳,获得10
36秒前
霸气雪珍发布了新的文献求助10
36秒前
风纪委员完成签到,获得积分20
37秒前
39秒前
39秒前
研友_VZG7GZ应助高兴笑蓝采纳,获得10
41秒前
fanhlong完成签到,获得积分10
42秒前
laihama发布了新的文献求助10
43秒前
LinglongCai完成签到 ,获得积分10
44秒前
44秒前
44秒前
包容城发布了新的文献求助10
45秒前
laoma发布了新的文献求助10
45秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2000
Very-high-order BVD Schemes Using β-variable THINC Method 1200
BIOLOGY OF NON-CHORDATES 1000
进口的时尚——14世纪东方丝绸与意大利艺术 Imported Fashion:Oriental Silks and Italian Arts in the 14th Century 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 550
The Collected Works of Jeremy Bentham: Rights, Representation, and Reform: Nonsense upon Stilts and Other Writings on the French Revolution 320
Generative AI in Higher Education 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3355819
求助须知:如何正确求助?哪些是违规求助? 2979615
关于积分的说明 8690871
捐赠科研通 2661111
什么是DOI,文献DOI怎么找? 1457075
科研通“疑难数据库(出版商)”最低求助积分说明 674646
邀请新用户注册赠送积分活动 665477