Palladium-Catalyzed Methylation of Alkynyl C(sp)–H Bonds with Dimethyl Sulfonium Ylides

A novel palladium-catalyzed methylation protocol for the synthesis of methyl-functionalized internal alkynes has been established. This methylation method is achieved through a C(sp)–C(sp3) bond formation process and represents a new synthetic application of sulfonium ylides.