布鲁顿酪氨酸激酶
断点群集区域
锡克
B细胞受体
癌症研究
酪氨酸激酶
生物
细胞生物学
B细胞
信号
刺猬信号通路
信号转导
免疫学
受体
抗体
遗传学
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2013-07-25
卷期号:13 (8): 578-591
被引量:271
摘要
The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis, differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central role in B cell neoplasia; for example, enhanced positive signalling or disrupted negative signalling downstream of the pre-BCR promotes B cell acute lymphocytic leukaemia. The emerging distinctions between tonic and chronic active BCR signalling have contributed to the identification of oncogenic targets downstream of BCR signalling in mature B cell neoplasms. Indeed, the encouraging results of several ongoing clinical trials that target the activity of phosphoinositide 3-kinase δ-isoform (PI3Kδ), Bruton tyrosine kinase (BTK) or spleen tyrosine kinase (SYK) downstream of the BCR highlight the therapeutic potential of inhibiting BCR signalling.
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