CTL公司*
养生
免疫系统
免疫学
抗逆转录病毒疗法
药品
细胞毒性T细胞
人类免疫缺陷病毒(HIV)
医学
病毒载量
生物
CD8型
药理学
内科学
生物化学
体外
作者
Nicoleta Tarfulea,ALLISON BLINK,Eric Nelson,David L. Turpin
标识
DOI:10.1142/s1793524511001209
摘要
Treatment of HIV infection has traditionally consisted of antiretroviral therapy (ART), a regimen of pharmaceutical treatments that often produces unwanted physical side effects and can become costly over long periods of time. Motivated by a way to control the spread of HIV in the body without the need for large quantities of medicine, researchers have explored treatment methods which rely on stimulating an individual's immune response, such as the cytotoxic lymphocyte (CTL) response, in addition to the usage of antiretroviral drugs. This paper investigates theoretically and numerically the effect of immune effectors in modeling HIV pathogenesis, our results suggest the significant impact of the immune response on the control of the virus during primary infection. Qualitative aspects (including positivity, stability, uncertainty, and sensitivity analysis) are addressed. Additionally, by introducing drug therapy, we analyze numerically the model to assess the effect of treatment. Our results show that the inclusion of the CTL compartment produces a higher rebound for an individual's healthy helper T-cell compartment than does drug therapy alone. Furthermore, we quantitatively characterize successful drugs or drug combination scenarios.
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