肌醇
己糖
生物化学
化学
环己醇
部分
生物
立体化学
受体
酶
作者
Frank Eisenberg,Arthur H. Bolden,Frank A. Loewus
标识
DOI:10.1016/0006-291x(64)90079-8
摘要
A homogenate of rat testis capable of incorporating carbon from glucose-U-C14 into inositol has been described in a previous publication (Eisenberg and Bolden, 1963). In an attempt to differentiate1 between a hexose moiety (Imai, 1963; Loewus and Kelly, 1962) and hexose fragments (Charalampous, 1957; Hauser and Finelli, 1963) as precursors of inositol, the conversion of specifically labeled glucose to inositol has now been studied in rat testis homogenate with the aid of a combined plant and chemical degradative system described previously (Loewus et al, 1962). Experimental evidence to be presented in this paper points unequivocally to a pathway of biosynthesis of inositol in the mammal involving cyclization of a six-carbon unit.
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