A Facile Synthesis of Novel Bis‐(indolyl)‐1,3,4‐oxadiazoles as Potent Cytotoxic Agents

ChemMedChemVolume 7, Issue 11 p. 1915-1920 Communication A Facile Synthesis of Novel Bis-(indolyl)-1,3,4-oxadiazoles as Potent Cytotoxic Agents Prof. Dalip Kumar, Corresponding Author Prof. Dalip Kumar [email protected] Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India) These authors contributed equally to this work. Dalip Kumar, Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India) Kavita Shah, Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA)Search for more papers by this authorV. Arun, V. Arun Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India)Search for more papers by this authorN. Maruthi Kumar, N. Maruthi Kumar Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India)Search for more papers by this authorGlen Acosta, Glen Acosta Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA)Search for more papers by this authorBrett Noel, Brett Noel Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA)Search for more papers by this authorProf. Kavita Shah, Corresponding Author Prof. Kavita Shah [email protected] Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA) These authors contributed equally to this work. Dalip Kumar, Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India) Kavita Shah, Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA)Search for more papers by this author Prof. Dalip Kumar, Corresponding Author Prof. Dalip Kumar [email protected] Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India) These authors contributed equally to this work. Dalip Kumar, Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India) Kavita Shah, Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA)Search for more papers by this authorV. Arun, V. Arun Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India)Search for more papers by this authorN. Maruthi Kumar, N. Maruthi Kumar Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India)Search for more papers by this authorGlen Acosta, Glen Acosta Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA)Search for more papers by this authorBrett Noel, Brett Noel Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA)Search for more papers by this authorProf. Kavita Shah, Corresponding Author Prof. Kavita Shah [email protected] Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA) These authors contributed equally to this work. Dalip Kumar, Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India) Kavita Shah, Department of Chemistry, Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA)Search for more papers by this author First published: 20 September 2012 https://doi.org/10.1002/cmdc.201200363Citations: 13 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract A recipe for potency: A novel series of bis(indolyl)-1,3,4-oxadiazoles was prepared from the corresponding hydrazide-hydrazones via iodobenzene diacetate-promoted oxidative cyclization. Evaluation against a panel of human cancer cell lines revealed that some derivatives possess potent cytotoxicity with tunable selectivity for different cancer types. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description cmdc_201200363_sm_miscellaneous_information.pdf72.6 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume7, Issue11November 2012Pages 1915-1920 RelatedInformation