自愈水凝胶
纳米孔
透明质酸
细胞包封
自愈
再生(生物学)
化学工程
伤口愈合
组织工程
材料科学
纳米技术
生物医学工程
高分子化学
工程类
病理
细胞生物学
生物
免疫学
替代医学
医学
遗传学
作者
Xin Zhang,Ying Li,Dannong He,Zhijie Ma,Kai Liu,Ke Xue,Haiyan Li
标识
DOI:10.1016/j.cej.2021.130677
摘要
Macroporous hydrogels have been attracting increasingly attention in cell delivery and tissue regeneration. Assembling microgels is an effective method for preparing macroporous hydrogels. However, current methods are limited to specific requirements to devices and hydrogel inherent properties. In addition, most of macroporous hydrogels lack self-healing abilities due to the permanent covalent crosslink of microgels. In this study, we proposed an effective strategy for preparing a bioactive macroporous self-healable hydrogel by producing microgels through squeezing methacrylated hyaluronic acid (MeHA) and 3-aminophenylboronic acid modified sodium alginate (SABA) nanoporous hydrogels through steel meshes and assembling the MeHA-SABA microgels under alkaline condition created by bioglass (BG) ionic products. Results demonstrated that the obtained macroporous hydrogels have significant larger pore size than nanoporous hydrogels, which facilitated cell infiltration, viability and proliferation. Meanwhile, the macroporous hydrogels had good self-healing abilities with the formation of dynamic B-O bonds. Furthermore, with the bioactivity of BG, the hydrogels could induce cell migration and ingrowth of cells and blood vessels. Thus, bioactivity and macroporous structure of the hydrogels can work synergistically to stimulate tissue regeneration. Taken together, this strategy is effective, simple and can be widely applied in fabricating binary components self-healable macroporous hydrogels as long as the two components are crosslinkable, indicating a great application potential in fabricating macroporous hydrogels for cell delivery and tissue regeneration.
科研通智能强力驱动
Strongly Powered by AbleSci AI