Brain functional specialization and cooperation in Parkinson’s disease

缘上回 功能磁共振成像 神经心理学 心理学 磁共振成像 神经科学 帕金森病 认知 额上回 神经组阅片室 病态的 医学 疾病 内科学 神经学 放射科
作者
Jinmei Sun,Xiaoran Gao,Qiang Hua,Rongrong Du,Pingping Liu,Tingting Liu,Jinying Yang,Bensheng Qiu,Gong‐Jun Ji,Panpan Hu,Kai Wang
出处
期刊:Brain Imaging and Behavior [Springer Science+Business Media]
卷期号:16 (2): 565-573 被引量:11
标识
DOI:10.1007/s11682-021-00526-4
摘要

Cerebral specialization and inter-hemispheric cooperation are two of the most prominent functional architectures of the human brain. Their dysfunctions may be related to pathophysiological changes in patients with Parkinson's disease (PD), who are characterized by unbalanced onset and progression of motor symptoms. This study aimed to characterize the two intrinsic architectures of hemispheric functions in PD using resting-state functional magnetic resonance imaging. Seventy idiopathic PD patients and 70 age-, sex-, and education-matched healthy subjects were recruited. All participants underwent magnetic resonance image scanning and clinical evaluations. The cerebral specialization (Autonomy index, AI) and inter-hemispheric cooperation (Connectivity between Functionally Homotopic voxels, CFH) were calculated and compared between groups. Compared with healthy controls, PD patients showed stronger AI in the left angular gyrus. Specifically, this difference in specialization resulted from increased functional connectivity (FC) of the ipsilateral areas (e.g., the left prefrontal area), and decreased FC in the contralateral area (e.g., the right supramarginal gyrus). Imaging-cognitive correlation analysis indicated that these connectivity were positively related to the score of Montreal Cognitive Assessment in PD patients. CFH between the bilateral sensorimotor regions was significantly decreased in PD patients compared with controls. No significant correlation between CFH and cognitive scores was found in PD patients. This study illustrated a strong leftward specialization but weak inter-hemispheric coordination in PD patients. It provided new insights to further clarify the pathological mechanism of PD.
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