壳聚糖
生物相容性
伤口愈合
化学
复合数
枯草芽孢杆菌
抗菌活性
自愈水凝胶
化学工程
白色念珠菌
肿胀 的
金黄色葡萄球菌
材料科学
核化学
微生物学
高分子化学
细菌
生物化学
有机化学
复合材料
免疫学
医学
工程类
生物
遗传学
作者
Miao Zhang,Xiaoni Qiao,Wenwei Han,Tianze Jiang,Fei Liu,Xia Zhao
标识
DOI:10.1016/j.carbpol.2021.118100
摘要
Moist, breathable and antibacterial microenvironment can promote cell proliferation and migration, which is beneficial to wound healing. Here, we fabricated a novel sodium alginate-chitosan oligosaccharide‑zinc oxide (SA-COS-ZnO) composite hydrogel by spontaneous Schiff base reaction, using aldehydated sodium alginate (SA), chitosan oligosaccharide (COS), and zinc oxide (ZnO) nanoparticles, which can provide a moist and antibacterial environment for wound healing. The porosity and swelling degree of SA-COS-ZnO hydrogel are 80% and 150%, respectively, and its water vapor permeability is 682 g/m2/24h. The composite hydrogel showed good biocompatibility to blood cells, 3T3 cells, and 293T cells, and significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and Bacillus subtilis. Moreover, the hydrogel showed a promoting effect on wound healing in a rat scald model. The present study suggests that marine carbohydrates composite hydrogels are promising in wound care management.
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