检出限
过氧化物酶
多金属氧酸盐
线性范围
材料科学
多孔性
兴奋剂
核化学
复合数
化学
酶
纳米技术
色谱法
有机化学
催化作用
光电子学
复合材料
作者
Mingqi Xu,Xiao Li,Jingquan Sha,Zhibo Tong,Qian Li,Chang Liu
标识
DOI:10.1002/chem.202100846
摘要
Abstract Developing highly active and sensitive peroxidase mimics for L ‐cysteine ( L ‐Cys) colorimetric detection is very important for biotechnology and medical diagnosis. Herein, polyoxometalate‐doped porous Co 3 O 4 composite (NiMo 6 @Co 3 O 4 ) was designed and prepared for the first time. Compared with pure and commercial Co 3 O 4 , NiMo 6 @Co 3 O 4 (n) composites exhibit the enhanced peroxidase‐mimicking activities and stabilities due to the strong synergistic effect between porous Co 3 O 4 and multi‐electron NiMo 6 clusters. Moreover, the peroxidase‐mimicking activities of NiMo 6 @Co 3 O 4 (n) composites are heavily dependent on the doping mass of NiMo 6 , and the optimized NiMo 6 @Co 3 O 4 (2) exhibits the superlative peroxidase‐mimicking activity. More importantly, a sensitive L ‐Cys colorimetric detection is developed with the sensitivity of 0.023 μM −1 and the detection limit at least 0.018 μM in the linear range of 1–20 μM, which is by far the best enzyme‐mimetic performances, to the best our knowledge.
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