Individual Participant Data Meta‐Analysis for Healthcare Research

Chapter 1 Individual Participant Data Meta-Analysis for Healthcare Research Richard D. Riley, Search for more papers by this authorLesley A. Stewart, Search for more papers by this authorJayne F. Tierney, Search for more papers by this author Richard D. Riley, Search for more papers by this authorLesley A. Stewart, Search for more papers by this authorJayne F. Tierney, Search for more papers by this author Book Editor(s):Richard D. Riley, Keele University, Keele, UKSearch for more papers by this authorJayne F. Tierney, MRC Clinical Trials Unit at UCL, London, UKSearch for more papers by this authorLesley A. Stewart, University of York, York, UKSearch for more papers by this author First published: 22 April 2021 https://doi.org/10.1002/9781119333784.ch1 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Summary This chapter presents the differences between individual participant data (IPD) and aggregate data, and outline why IPD meta-analysis projects are increasingly needed. An IPD meta-analysis project, therefore, involves the collection, checking, harmonisation and synthesis of IPD from multiple studies to answer particular research questions. A conventional meta-analysis uses aggregate data, rather than IPD. The growth of IPD meta-analysis projects reflects their potential to revolutionise healthcare research, especially as they align with three major contemporary initiatives: reducing research waste, data sharing, and personalised healthcare. Leading medical journals require data-sharing statements, with some even enforcing the sharing of IPD on request. This has led to dedicated data sharing platforms and repositories being established to house IPD from existing studies. IPD meta-analysis projects are central to modern evidence synthesis in healthcare. The chapter also presents an overview of the key concepts discussed in this book. Individual Participant Data Meta‐Analysis: A Handbook for Healthcare Research RelatedInformation