Extended Versus Standard Complete Mesocolon Excision in Sigmoid Colon Cancer: A Multicentre Randomised Controlled Trial.

医学 结直肠癌 乙状结肠 外科 随机对照试验 结肠切除术 荟萃分析 直肠 乙状窦函数
作者
P Planellas,F. Marinello,G Elorza,Thomas Golda,R Farrés,E Espín-Basany,José María Enríquez-Navascués,Esther Kreisler,Lídia Cornejo,Antoni Codina-Cazador
出处
期刊:Annals of Surgery [Lippincott Williams & Wilkins]
被引量:1
标识
DOI:10.1097/sla.0000000000005161
摘要

Objective To evaluate whether extended complete mesocolic excision (e-CME) for sigmoid colon cancer improves oncological outcomes without compromising morbidity or functional results. Background In surgery for cancer of the sigmoid colon and upper rectum, s-CME removes the lymphofatty tissue surrounding the inferior mesenteric artery (IMA), but not the lymphofatty tissue surrounding the portion of the inferior mesenteric vein that does not run parallel to the IMA. Evidence about the safety and efficacy of extending CME to include this tissue is lacking. Methods This single-blind study randomized sigmoid cancer patients at four centers to undergo e-CME or s-CME. The primary outcome was the total number of lymph nodes harvested. Secondary outcomes included disease-free and overall survival at 2 years, morbidity, and bowel and genitourinary function. Clinicaltrials.gov: NCT03107650. Results We analyzed 93 patients (46 e-CME and 47 s-CME). Perioperative outcomes were similar between groups. No differences between groups were found in the total number of lymph nodes harvested [21 (IQR, 14-29) in e-CME vs. 20 (IQR, 15-27) in s-CME, p = 0.873], morbidity (p = 0.829), disease-free survival (p = 0.926), or overall survival (p = 0.564). The extended specimen yielded a median of 1 lymph node (range, 0-6), none of which were positive.Bowel function recovery was similar between arms at all timepoints. Males undergoing e-CME had worse recovery of urinary function (p = 0.026) and sexual function (p = 0.046). Conclusions Extending lymphadenectomy to include the IMV territory did not increase the number of lymph nodes or improve local recurrence or survival rates.
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