Wnt信号通路
癌症研究
癌变
甲状腺癌
小RNA
下调和上调
甲状腺癌
生物
癌基因
肿瘤进展
癌症
体内
信号转导
甲状腺
细胞生物学
基因
内分泌学
遗传学
细胞周期
作者
Dongfang Bai,Chong Guo,Aimin Wang,Guolong Pang,Jing Gao,Chuan Wang,Dapeng Zhao,Jie Yang,Jianmin Ren
标识
DOI:10.1016/j.prp.2021.153561
摘要
Long noncoding RNAs (lncRNAs) play crucial roles in the regulation of human thyroid cancer (TC), including papillary thyroid carcinoma (PTC); PTC is the most common pathological subtype of TC. To date, the expression, function, and mechanism of the lncRNA CASC15 in PTC remain unclear. The present study results showed that CASC15 was overexpressed in PTC tissues compared with normal tissues and acted as a potent oncogene to promote the proliferation and tumorigenesis of PTC cells both in vitro and in vivo. Mechanistic studies demonstrated that CASC15 could serve as an endogenous miRNA sponge to absorb and downregulate miR-7151-5p, thereby preventing the inhibition of WNT7A during PTC progression. Furthermore, the study demonstrated that CASC15 activated the WNT/β‑catenin signaling pathway by upregulating WNT7A in PTC. Taken together, our findings identified CASC15 as a potential diagnostic marker or therapeutic target for PTC progression. DATA AVAILABILITY: Please contact the corresponding author for a data request.
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