Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases

Journal of Food BiochemistryVolume 45, Issue 5 e13724 REVIEW Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases Shiyu Liu, Shiyu Liu State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: ​Investigation, Visualization, Writing - original draftSearch for more papers by this authorPingting Xiao, Pingting Xiao State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: ConceptualizationSearch for more papers by this authorYujia Kuang, Yujia Kuang State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: Writing - review & editingSearch for more papers by this authorJinhua Hao, Jinhua Hao State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: Writing - review & editingSearch for more papers by this authorTianqing Huang, Tianqing Huang State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: ​InvestigationSearch for more papers by this authorEhu Liu, Corresponding Author Ehu Liu liuehu2011@163.com orcid.org/0000-0002-7281-210X State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Correspondence Ehu Liu, State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing, P.R. China. Email: liuehu2011@163.com Contribution: Funding acquisition, SupervisionSearch for more papers by this author Shiyu Liu, Shiyu Liu State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: ​Investigation, Visualization, Writing - original draftSearch for more papers by this authorPingting Xiao, Pingting Xiao State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: ConceptualizationSearch for more papers by this authorYujia Kuang, Yujia Kuang State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: Writing - review & editingSearch for more papers by this authorJinhua Hao, Jinhua Hao State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: Writing - review & editingSearch for more papers by this authorTianqing Huang, Tianqing Huang State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Contribution: ​InvestigationSearch for more papers by this authorEhu Liu, Corresponding Author Ehu Liu liuehu2011@163.com orcid.org/0000-0002-7281-210X State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China Correspondence Ehu Liu, State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing, P.R. China. Email: liuehu2011@163.com Contribution: Funding acquisition, SupervisionSearch for more papers by this author First published: 15 April 2021 https://doi.org/10.1111/jfbc.13724Citations: 1 Shiyu Liu and Pingting Xiao are the authors contributed to this paper equally. Funding information We greatly appreciate financial support from the National Natural Science Foundation of China (81922072 and 81973443), “Double First-Class” University project (CPU2018PZQ16 and CPU2018GF04) and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Sea buckthorn (Hippophae rhamnoides L., SBT) is being used as a folk medicine for their diverse medicinal properties. Flavonoids are generally considered as the main bioactive and characteristic ingredients in SBT. This review was conducted using a comprehensive literature search on the chemical components, quality control, pharmacokinetics of flavonoids from SBT (FSBT). Particularly, we highlighted the therapeutic potential in metabolic diseases and clinical applications of FSBT. More than 95 flavonoids have been identified from SBT. Although the oral bioavailability of FSBT was relatively low, FSBT displays significant effect on the regulation of metabolism to ameliorate metabolic disorders and their complications. There is a heightened need to explore the bioactive compounds in SBT and mechanism(s) of action of FSBT in order to fully understand the pathways of their activities. Practical applications For years, due to the increasing emergence of metabolic syndrome and diverse functions of FSBT in regulating metabolism, they can be efficiently utilized for human health and have an urgent need to become a hotspot for research. This review will broaden the understanding of FSBT, providing some directions for further development and expanding the therapeutic applications of FSBT. CONFLICT OF INTEREST The authors declared that they have no conflict of interest. Open Research DATA AVAILABILITY STATEMENT The data used to prepare the manuscript are present in the main text. The materials are available from the corresponding author upon reasonable request. Citing Literature Volume45, Issue5May 2021e13724 RelatedInformation