手性(物理)
超分子化学
脂肪酶
生物催化
纳米技术
催化作用
化学
材料科学
自组装
酶
生物化学
反应机理
有机化学
分子
物理
夸克
量子力学
手征对称破缺
Nambu–Jona Lasinio模型
作者
Meng Sun,Shiqiao Peng,Lei Nie,Yunqing Zou,Yang Li,Laiben Gao,Xiaoqiu Dou,Changli Zhao,Chuanliang Feng
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-09-07
卷期号:15 (9): 14972-14984
被引量:11
标识
DOI:10.1021/acsnano.1c05212
摘要
How the three-dimensional (3D) chiral environment affects the biocatalysis remains an important issue, thereby inspiring the development of a microenvironment that highly mimics the natural features of enzyme to guarantee enhanced biocatalysis. In this study, two gelators bearing d/l-phenylalanine as chiral centers are designed to construct the 3D chiral catalytic microenvironment for enhancing the biocatalysis of lipase. Such a microenvironment is programmed through chiral transmission of chirality from molecular chirality to achiral polymers. It shows that the chirality of the microenvironment evidently influences the catalytic efficiency of immobilized lipase inside the system, and the 3D microenvironment constructed by right-handed helical nanostructures can enhance the catalytic activity of lipase inside as high as 10-fold for catalyzing 4-nitrophenyl palmitate (NPP) to 4-nitrophenol (NP) and 1.4-fold for catalyzing lipids to triglycerides (TGs) in 3T3-L1 cells than that of the achiral microenvironment. Moreover, the 3D chiral microenvironment has the merits of good catalytic efficiency, high storage stability, and efficient recyclability. This strategy of designing a 3D chiral microenvironment suitable for biocatalysis will overcome the present limitations of enzymatic immobilization in traditional materials and enhance the understanding of biocatalysis.
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