造血
疾病
体细胞
生物
干细胞
癌症的体细胞进化
免疫学
谱系(遗传)
遗传学
医学
内科学
基因
作者
David A. Alagpulinsa,Mabel Toribio,Iad Alhallak,Robert J. Shmookler Reis
标识
DOI:10.1016/j.molmed.2022.03.002
摘要
Hematopoietic stem cells (HSCs) are polyfunctional, regenerating all blood cells via hematopoiesis throughout life. Clonal hematopoiesis (CH) is said to occur when a substantial proportion of mature blood cells is derived from a single dominant HSC lineage, usually because these HSCs have somatic mutations that confer a fitness and expansion advantage. CH strongly associates with aging and enrichment in some diseases irrespective of age, emerging as an independent causal risk factor for hematologic malignancies, cardiovascular disease, adverse disease outcomes, and all-cause mortality. Defining the molecular mechanisms underlying CH will thus provide a framework to develop interventions for healthy aging and disease treatment. Here, we review the most recent advances in understanding the molecular basis of CH in health and disease.
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