硼酸
聚合物
自愈水凝胶
化学
粘蛋白
粘附
水溶液
化学工程
高分子化学
有机化学
生物化学
工程类
作者
Masaki Nakahata,Naoki Tominaga,Kimiko Saito,Keita Nishiyama,Yuya Tanino,Kiyoshiro Saiki,Masaru Kojima,Shinji Sakai
标识
DOI:10.1002/mabi.202200055
摘要
Abstract Mucin‐containing bio‐synthetic hybrid hydrogel is successfully formed under physiological conditions upon mixing aqueous solutions of native mucin and synthetic polymers carrying boronic acids. The mechanical properties and stability of the hydrogel in physiological solutions, e.g., cell culture media, are tunable depending on the boronic acid content of polymers. The hydrogel dissolved in the physiological solutions releases native mucin and boronic acid‐containing polymer, which can control the adhesion of mammalian cells to the surface.
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