神经红蛋白
肌红蛋白
珠蛋白
血红素蛋白
血红素
化学
二硫键
结晶学
立体化学
生物化学
血红蛋白
酶
作者
Li-Juan Sun,Hong Yuan,Lu Yu,Shu‐Qin Gao,Ge Wen,Xiangshi Tan,Ying‐Wu Lin
摘要
An artificial disulfide bond (Cys46-Cys61) was designed in the heme distal site of myoglobin, which regulates the conformation of the heme distal His64 and the protein reactivity, as confirmed by X-ray crystallography, EPR, and kinetic UV-vis studies. This study shows the successful design of a disulfide bond with suitable positions in globins, conferring a structure and function like those of the native human neuroglobin.
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