斑马鱼
肌萎缩侧索硬化
神经化学
神经退行性变
神经科学
生物
失智症
帕金森病
亨廷顿病
疾病
痴呆
遗传学
医学
基因
病理
作者
Alim A. Bashirzade,Konstantin N. Zabegalov,Andrey D. Volgin,Alisa S. Belova,Konstantin A. Demin,Murilo S. de Abreu,V. Ya. Babchenko,Kseniya A. Bashirzade,Konstantin Yenkoyan,Maria A. Tikhonova,Tamara G. Amstislavskaya,Allan V. Kalueff
标识
DOI:10.1016/j.neubiorev.2022.104679
摘要
Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain disorders. Their complex pathogenesis commonly includes genetic and neurochemical deficits, misfolded protein toxicity, demyelination, apoptosis and mitochondrial dysfunctions. Albeit differing in specific underlying mechanisms, neurodegenerative disorders typically display evolutionarily conserved mechanisms across taxa. Here, we review the role of zebrafish models in recapitulating major human and rodent neurodegenerative conditions, demonstrating this species as a highly relevant experimental model for research on neurodegenerative diseases, and discussing how these fish models can further clarify the underlying genetic, neurochemical, neuroanatomical and behavioral pathogenic mechanisms.
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