Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study

穹窿 边缘系统 自闭症谱系障碍 部分各向异性 心理学 白质 自闭症 磁共振弥散成像 双胞胎研究 钩束 遗传力 纤维束成像 神经科学 听力学 发展心理学 医学 磁共振成像 遗传学 海马体 生物 中枢神经系统 放射科
作者
Linyan Fu,Chunyan Li,Yun Li,Xin Cheng,Xiwen Cui,Jiying Jiang,Ning Ding,Hui Fang,Tianyu Tang,Xiaoyan Ke
出处
期刊:Autism Research [Wiley]
卷期号:15 (4): 628-640 被引量:9
标识
DOI:10.1002/aur.2686
摘要

Abstract Although the limbic system is closely related to emotion and social behaviors, little is known about the integrity of limbic pathways and how genetics influence the anatomical abnormalities of limbic networks in children with autism spectrum disorder (ASD). Therefore, we used an ASD twin study design to evaluate the microstructural integrity and autism‐related differences in limbic pathways of young children with ASD and to estimate the heritability of limbic tracts microstructure variance. We obtained diffusion tensor imaging scans from 33 pairs of twins with ASD aged 2–9 years and 20 age‐matched typically developing children. The ACE model was used to estimate the relative effects of additive genetic factors (A), shared environmental factors (C) and specific environmental factors (E) on the variability of diffusivity measurements. We found a significant decrease in fractional anisotropy (FA) in the bilateral fornix and uncinate fasciculus (UF), as well as increased mean diffusivity (MD) and radial diffusivity (RD) in the bilateral fornix and right UF of ASD children. Correlation analysis showed that FA, MD, and lateralization indices of UF were correlated with autism diagnostic observation schedule scores. The ACE model revealed that genetic effects may drive some of the variability of microstructure in the bilateral fornix, cingulum, and left UF. In conclusion, in children with ASD, there are abnormalities in the white matter microstructure of the limbic system, which is related to the core symptoms; these abnormalities may be related to the relative contribution of genetic and environmental effects on specific tracts. Lay Summary Autism spectrum disorder (ASD) children have abnormal white matter structure in limbic system related to ASD symptoms, and genetic factors play an important role in the development of limbic tracts.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
欣喜宛亦完成签到 ,获得积分10
3秒前
3秒前
他也蓝发布了新的文献求助10
4秒前
芋泥面包发布了新的文献求助10
4秒前
liyb完成签到,获得积分10
5秒前
绵羊座鸭梨完成签到 ,获得积分10
5秒前
orixero应助drxiao采纳,获得30
6秒前
千冬完成签到,获得积分10
9秒前
李凭中国弹箜篌完成签到,获得积分10
9秒前
11秒前
浪客完成签到 ,获得积分10
11秒前
韩soso完成签到,获得积分10
12秒前
13秒前
完美的从波完成签到,获得积分10
13秒前
SilvanYang完成签到,获得积分10
14秒前
张建文完成签到,获得积分10
15秒前
16秒前
17秒前
枫泾发布了新的文献求助10
17秒前
17秒前
JamesPei应助xiaohuangya采纳,获得10
18秒前
18秒前
妖孽发布了新的文献求助10
19秒前
19秒前
田様应助June采纳,获得10
19秒前
20秒前
完美大神完成签到 ,获得积分10
21秒前
21秒前
hunbaekkkkk发布了新的文献求助10
22秒前
22秒前
syuen发布了新的文献求助10
23秒前
23秒前
23秒前
23秒前
啊薇儿发布了新的文献求助10
24秒前
24秒前
25秒前
26秒前
方方发布了新的文献求助30
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976267
求助须知:如何正确求助?哪些是违规求助? 3520472
关于积分的说明 11203425
捐赠科研通 3257089
什么是DOI,文献DOI怎么找? 1798589
邀请新用户注册赠送积分活动 877785
科研通“疑难数据库(出版商)”最低求助积分说明 806523