神经影像学
认知
神经功能成像
心理学
帕金森病
心理信息
疾病
科克伦图书馆
执行职能
神经科学
医学
正电子发射断层摄影术
认知障碍
荟萃分析
梅德林
内科学
法学
政治学
作者
Quentin Devignes,Renaud Lopes,Kathy Dujardin
标识
DOI:10.1016/j.parkreldis.2022.02.006
摘要
Abstract
Background
Mild cognitive impairment in Parkinson's disease (PD-MCI) is heterogenous and cognitive subtypes have been identified. However, the anatomo-functional bases of each subtype remain partly unknown. Objective
To propose a description of the current literature on neuroimaging findings associated with cognitive subtypes of PD-MCI. Methods
PubMed/Medline, Embase, PsycINFO and the Cochrane Library databases were searched (until April 2021). Studies comparing PD-MCI cognitive subtypes with healthy controls (HC) and PD patients with normal cognition (PD-NC) on any neuroimaging outcome were included. Results
Ten studies met the inclusion criteria. Six used structural MRI methods, two functional MRI methods, one electroencephalography and five positron or single-photon emission tomography. Most studies (n = 8) determined PD-MCI subtypes based on memory impairment and two based on executive impairment. Compared with HC and/or PD-NC, brain modifications were found in PD patients (a) with amnestic MCI and, to a lesser extent, non-amnestic MCI in occipital, parietal and temporal regions, (b) with executive MCI in frontal and striatal regions and (c) with non-executive MCI in posterior cortical regions. Conclusions
Very few neuroimaging studies have considered cognitive heterogeneity that exists within PD-MCI, making it difficult to draw robust conclusions regarding brain modifications associated with specific subtypes. Given the promising potential of neuroimaging methods in both clinical practice and research, further studies are needed to overcome the limitations of the current literature.
科研通智能强力驱动
Strongly Powered by AbleSci AI