Dimethyl Sulfoxide as Methyl Source for the Synthesis of Quinazolinones under Metal‐Free Conditions

Abstract An efficient synthesis of biologically important quinazolinones via using dimethyl sulfoxide as a synthon has been developed. This reaction proceeds smoothly to obtain the corresponding quinazolinones products in good yield under metal free conditions and shows an excellent functional group tolerance. A preliminary mechanistic study indicates that the C2 hydrogen of the synthesized heterocycles come from the dimethyl sulfoxide.