Protein polarization: Spatiotemporal precisions in cell division and differentiation

Specification of cell polarity is vital to normal cell growth, morphogenesis, and function. As other eukaryotes, plants generate cellular polarity that is coordinated with tissue polarity and organ axes. In development, new cell types are generated by stem-cell division and differentiation, a process often involving proteins that are polarized to cortical domains at the plasma membrane. In the past decade, pioneering work using the model plant Arabidopsis identified multiple proteins that are polarized in dividing cells to instruct divisional behaviors and/or specify cell fates. In this review, we use these polarized cell-division regulators as example to summarize key mechanisms underlying protein polarization in plant cells. Recent progress underscores that self-organizing amplification processes are commonly involved in establishing cell polarity, and cellular polarity is influenced by both tissue-level and local mechanochemical cues. In addition, protein polarization during asymmetric cell division shows a distinct feature of temporal control in the stomatal lineage. We further discuss possible coordination between protein polarization and the progression of cell cycle in this developmental context.