Objective: To investigate the feasibility, safety and efficacy of transoral robotic surgery (TORS) in the treatment of lingual thyroglossal duct cyst (LTGDC). Methods: The clinical data of 10 patients with LTGDC treated with TORS in Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology from May 2017 to November 2020 were analyzed retrospectively,including 6 males and 4 females, aged 5-44 years. The cysts were fully exposed, and resection usually started from the cephalic side of lesions. The range of resection was 3 to 5 mm away from the lesions, and partial hyoid bone was removed if necessary. Intra-operative robotic set-up time,operation time and estimated blood loss,and post-operative local bleeding, dyspnea and recovery time for oral intake were analyzed. SPSS 12.0 software was used for statistical analysis. Results: The cysts in all 10 patients were successfully resected by TORS with da Vinci Si surgical system. The mean robotic set-up and exposure time, operation time, estimated intraoperative blood loss and recovery time for oral intake were (15.5±7.1) min, (17.6±7.4) min, (8.9±6.4)ml and (2.3±2.2)days, respectively. No patient required tracheostomy intra-or post-operatively, and no symptoms of airway obstruction, postoperative bleeding, pharyngeal fistula, hoarseness and neurological impairment occurred after operation. The patients were followed up for 5 to 47 months, with median follow-up time of 17 months, and no recurrence was observed. Conclusion: TORS is safe and feasible for resection of LTGDC, with rapid recovery and low recurrence rate.目的: 探讨经口机器人手术(transoral robotic surgery,TORS)治疗舌根部甲状舌管囊肿(lingual thyroglossal duct cyst,LTGDC)的可行性、安全性及术后疗效。 方法: 回顾性分析2017年5月至2020年11月期间华中科技大学同济医学院附属同济医院收治的10例行TORS治疗的LTGDC患者的临床资料,其中男6例,女4例,年龄5~44岁。手术中充分暴露病变,从囊肿头侧开始切除,切除范围以距病变外侧3~5 mm为宜,必要时可切除部分舌骨。分析术中机器人设置时间、手术时间、术中出血量,术后有无局部出血、呼吸困难,以及经口进食时间等指标。应用SPSS 12.0进行统计学分析。 结果: 本组10例LTGDC患者,均在达芬奇机器人辅助下经口入路顺利完成囊肿切除术,机器人设置时间(15.5±7.1)min,手术时间(17.6±7.4)min,术中出血量(8.9±6.4)ml,术后恢复经口进食时间为(2.3±2.2)d。所有患者术中术后均未行气管切开术,术后均未出现气道梗阻、出血、咽瘘、声嘶、神经功能受损症状。术后随访5~47个月,中位随访时间17个月,未见复发病例。 结论: 达芬奇机器人辅助下经口入路LTGDC切除术安全可行,术后恢复快,复发率低。.