吡啶
化学
亲核细胞
戒指(化学)
转化(遗传学)
吡啶类化合物
药物化学
组合化学
有机化学
催化作用
生物化学
基因
作者
Xiaoxia Duan,Rui Sun,Juan Tang,Shun Li,Yang Xiao,Xueli Zheng,Ruixiang Li,Hua Chen,Haiyan Fu,Maolin Yuan
标识
DOI:10.1021/acs.joc.2c00614
摘要
Nucleophilic recyclization of pyridinium salts involving a CCN interchange ring transformation for the synthesis of 2-methylnicotinonitrile derivatives was herein developed. 3-Aminocrotononitrile (3-ACN) produced in situ from CH3CN acted as a C-nucleophile, as well as the source of CH3 and CN groups, which was supported by isotope-labeling and control experiments.
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