材料科学
PLGA公司
肺表面活性物质
水溶液
粘附
制作
模具
聚苯乙烯
胶粘剂
疏水效应
化学工程
纳米技术
乳状液
溶解
药物输送
生物医学工程
复合材料
聚合物
图层(电子)
有机化学
化学
纳米颗粒
医学
替代医学
病理
工程类
作者
Derek Jang,Jie Tang,Steven P. Schwendeman,Mark R. Prausnitz
标识
DOI:10.1021/acsami.2c05795
摘要
Microneedle (MN) patches enable simple self-administration of drugs via the skin. In this study, we sought to deliver drug-loaded microspheres (MSs) using MN patches and found that the poly(lactic-co-glycolic acid) (PLGA) MSs failed to localize in the MN tips during fabrication, thereby decreasing their delivered dose and delivery efficiency into skin. We determined that surface interactions between the hydrophobic MSs and the poly(dimethylsiloxane) (PDMS) mold caused MSs to adhere to the mold surface during casting in aqueous formulations, with hydrophobic interactions largely responsible for adhesion. Further studies with polystyrene MSs that similarly carry a negative charge like the PLGA MSs demonstrated both repulsive electrostatic interactions as well as adhesive hydrophobic interactions. Reducing hydrophobic interactions by addition of a surfactant or modifying mold surface properties increased MS loading into MN tips and delivery into porcine skin ex vivo by 3-fold. We conclude that surface interactions affect the loading of hydrophobic MSs into MN patches during aqueous fabrication procedures and that their modulation with the surfactant can increase loading and delivery efficiency.
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