五味子
蛋白激酶B
PI3K/AKT/mTOR通路
MAPK/ERK通路
药理学
作用机理
化学
细胞凋亡
五味子
木脂素
传统医学
医学
生物化学
信号转导
中医药
立体化学
体外
病理
替代医学
作者
Zehao Xiao,Wu Xiao,Guilin Li
摘要
Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and ability to protect the liver, protect against ischemia-reperfusion (I/R) injury, suppress osteoclast formation, and improve learning and memory. Its mechanism may be related to the antioxidant, anti-inflammatory, and antiapoptotic properties of Sch A through the MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways. This is the first review of the recent studies on the pharmacological mechanism of Sch A.
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