自愈水凝胶
隐形眼镜
生物污染
药物输送
化学
生物粘附
材料科学
单体
接触角
化学工程
高分子化学
聚合物
纳米技术
有机化学
生物化学
复合材料
医学
工程类
眼科
膜
作者
Jing Zhang,Sunxiang Qian,Lingdong Chen,Minmin Wu,Yukui Zhang,Xiaozhou Mou,Jie Feng
标识
DOI:10.1016/j.eurpolymj.2022.111037
摘要
Antifouling and antibacterial zwitterionic hydrogels were prepared and used as soft contact lens for ocular bacterial infections therapy. The zwitterionic hydrogels are mainly composed of zwitterionic segments and tuned by a small part of other hydrophilic and hydrophobic monomers for optimal properties, which achieve high transmittance of 94% in the range of visible wavelength, high water content, good water retention rate and stable dehydration-rehydration property. Moreover, even after five co-culture cycles with non-specific protein and bacteria, the zwitterionic hydrogels showed much better antifouling properties than the commercial contact lens (CL). Besides, functional monomer acrylic acid was incorporated in the zwitterionic hydrogels to load norfloxacin (NF) and control its release by molecular imprinting technology. Thus, the zwitterionic hydrogels have significant in vitro and in vivo bactericidal function. By constructing a conjunctivitis model of rabbits, we found that delivery of NF by the zwitterionic hydrogels had a better therapeutic outcome than delivery of NF through eye-drops. These results indicate that the zwitterionic hydrogels are competitive candidates for the application of wearing contact lens and ophthalmic drug delivery.
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