立体化学
奥西多尔
单加氧酶
生物合成
黄素组
化学
对映体药物
对映选择合成
生物化学
基因
酶
细胞色素P450
催化作用
作者
Amy E. Fraley,Hong Tran,Ashootosh Tripathi,Sean A. Newmister,Samantha P. Kelly,Hikaru Kato,Sachiko Tsukamoto,Shengying Li,Robert M. Williams,David H. Sherman
标识
DOI:10.26434/chemrxiv.11302604
摘要
<div> <div> <div> <p>The fungal indole alkaloids are a unique class of complex molecules that have a characteristic bicyclo[2.2.2]diazaoctane ring and frequently contain a spiro-oxindole moiety. While various strains produce these compounds, an intriguing case involves the formation of individual antipodes by two unique species of fungi in the generation of the potent anticancer agents (+)- and (-)-notoamide A. NotI and NotI′ have been characterized as flavin-dependent monooxygenases that catalyze epoxidation and semi-Pinacol rearrangement to form the spiro-oxindole center within these molecules. This work elucidates a key step in the biosynthesis of the notoamides and provides an evolutionary hypothesis regarding a common ancestor for production of enantiopure notoamides. </p> </div> </div> </div>
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