双精氨酸易位途径
转位酶
生物发生
生物
生物化学
易位
细胞质
细胞生物学
转运蛋白
蛋白质靶向
蛋白质折叠
染色体易位
膜转运蛋白
膜蛋白
大肠杆菌
基因
膜
作者
Philip A. Lee,Danielle Tullman‐Ercek,George Georgiou
出处
期刊:Annual Review of Microbiology
[Annual Reviews]
日期:2006-07-07
卷期号:60 (1): 373-395
被引量:319
标识
DOI:10.1146/annurev.micro.60.080805.142212
摘要
The twin-arginine translocation (Tat) pathway is responsible for the export of folded proteins across the cytoplasmic membrane of bacteria. Substrates for the Tat pathway include redox enzymes requiring cofactor insertion in the cytoplasm, multimeric proteins that have to assemble into a complex prior to export, certain membrane proteins, and proteins whose folding is incompatible with Sec export. These proteins are involved in a diverse range of cellular activities including anaerobic metabolism, cell envelope biogenesis, metal acquisition and detoxification, and virulence. The Escherichia coli translocase consists of the TatA, TatB, and TatC proteins, but little is known about the precise sequence of events that leads to protein translocation, the energetic requirements, or the mechanism that prevents the export of misfolded proteins. Owing to the unique characteristics of the pathway, it holds promise for biotechnological applications.
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