光动力疗法
介孔二氧化硅
阿霉素
材料科学
纳米颗粒
氯
纳米技术
介孔材料
癌症研究
化学
癌症
化疗
医学
生物化学
有机化学
内科学
催化作用
作者
Jinghua Sun,Wei Zhang,Dongyang Zhang,Jianliang Shen,Cai‐Ping Tan,Liang‐Nian Ji,Zong‐Wan Mao
标识
DOI:10.1177/0885328218758925
摘要
A multimodal nanocarrier based on mesoporous silica nanoparticles (MSNs) is developed to co-delivery photosensitizer chlorin e6 (Ce6) and chemotherapeutic agent doxorubicin (Dox) for cancer combination therapy. Ce6 was covalently conjugated with mesoporous silica nanoparticles, which could increase the loading efficiency, and allowed for photodynamic therapy. Doxorubicin was loaded into the pores of mesoporous silica nanoparticles to afford the dual drug delivery system [email protected] These hybrid nanoparticles have an average diameter of about 100 nm and slightly negative charge of about −17 mV. The [email protected] nanoparticles could efficiently enter into cancer cells. The cellular reactive oxygen species level in treated cells increased about 17 times, upon 660 nm light irradiation (10 mW/cm2, 2 min). More importantly, [email protected] exhibited excellent synergistic effect through combining chemotherapy and photodynamic therapy against A549 lung cancer cells. Our work provides an effective strategy for anticancer drug delivery and combination therapy.
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