NMDA受体
受体
外围设备
信号转导
氧化应激
生物
内分泌学
内科学
药理学
医学
细胞生物学
作者
Marie McGee,Abdel A. Abdel‐Rahman
出处
期刊:Journal of Cardiovascular Pharmacology
[Ovid Technologies (Wolters Kluwer)]
日期:2016-04-19
卷期号:68 (2): 97-105
被引量:26
标识
DOI:10.1097/fjc.0000000000000398
摘要
Abstract: Excellent reviews on central N-methyl- d -aspartate receptor (NMDAR) signaling and function in cardiovascular regulating neuronal pools have been reported. However, much less attention has been given to NMDAR function in peripheral tissues, particularly the heart and vasculature, although a very recent review discusses such function in the kidney. In this short review, we discuss the NMDAR expression and complexity of its function in cardiovascular tissues. In conscious (contrary to anesthetized) rats, activation of the peripheral NMDAR triggers cardiovascular oxidative stress through the PI3K-ERK1/2-NO signaling pathway, which ultimately leads to elevation in blood pressure. Evidence also implicates Ca 2+ release, in the peripheral NMDAR-mediated pressor response. Despite evidence of circulating potent ligands (eg, D-aspartate and l -aspartate, l -homocysteic acid, and quinolinic acid) and also their coagonist (eg, glycine or d -serine), the physiological role of peripheral cardiovascular NMDAR remains elusive. Nonetheless, the cardiovascular relevance of the peripheral NMDAR might become apparent when its signaling is altered by drugs, such as alcohol, which interact with the NMDAR or its downstream signaling mechanisms.
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