Advance in Research and Development of Natural Products from Marine Microorganisms*

Giving a general summary of the strategies for exploring natural products from marine microorganisms,this article reviews the advances in research and development of natural products derived from marine microorganisms.Different sample pre-treated protocols,isolation media and new cultivation methods are introduced in this article in order to obtain marine-specific microorganisms as well as increase the diversity of marine microorganisms.Metagenomics screening and genome sequencing based mining as new strategies,are addressed to discover natural products from difficult-cultivated or uncultivated microorganisms and ‘silent’ natural products,respectively.Finally,heterologous biosynthesis,combinatorial biosynthesis and ribosome engineering used for exploring marine natural products are illustrated,and detailed examples are presented to show the exploring of marine natural products.