Objective: To observe the safety and curative effects of treating advanced gastric cancer with combined capecitabine and oxaliplatin.Methods: Thirty two patients with advanced gastric cancer were treated with capecitabine and oxaliplatin for two courses to observe the curative effects,clinical profit,toxic reactions and side effects.Results: The total effective rate reached 56.3%.The patients who hade clinical profit were 84.3% and with slight toxic reactions and side effects,no patients dead for toxic reactions of chemotherapy. Conclusion: The chemotherapy with capecitabine and oxaliplatin combined has more advantages in treating advanced gastric cancer.It is more effective,more convenient and with slight toxic reactions and side effects is an effective chemotherapy regimen for advanced gastric cancer.